Research and Publications

My research work has focused on understanding the biological mechanisms that underlie complex skin diseases, with particular emphasis on fibrosis, abnormal wound healing, and rare inherited dermatologic conditions. This work has spanned basic, translational, and clinical domains and has informed both scientific understanding and clinical practice.

Research Focus Areas

• Keloidal scarring, skin fibrosis and abnormal wound healing

• Keloid pathogenesis and extracellular matrix biology

• Genetic and molecular mechanisms of skin disease

• Translational approaches to complex dermatologic conditions

Translational Perspective

A central feature of my work has been the integration of laboratory-based investigation with clinical observation. By studying disease mechanisms in parallel with patient presentations, my research has emphasized biological relevance and clinical applicability. This translational perspective continues to inform how I approach complex and treatment-resistant skin conditions in practice.

Selected Publications

Below is a selection of peer-reviewed publications representative of my work.

Hamzehlou S, Vishlaghi N, Shelton JM, Levi B, Xing C, Glass DA 2nd. RUNX2 regulates aberrant expression of collagen genes in keloid fibroblasts. J Invest Dermatol. 2025 Dec 11:S0022-202X(25)03631-0. doi: 10.1016/j.jid.2025.11.020. Epub ahead of print. PMID: 41389955.

Vaish M, Hadeler E, Glass DA 2nd. Therapeutic effect of hydroxyurea in treating refractory keloids. JAAD Case Rep. 2024 Nov 23;66:74-76. doi: 10.1016/j.jdcr.2024.10.032. PMID: 41245808; PMCID: PMC12614440.

Hamzehlou S, Mortlock RD, Echeandia-Francis C, Zhou J, Xing C, Agim NG, Choate KA, Glass DA 2nd. Erythrokeratodermia-Cardiomyopathy Syndrome: Expanding the DSP Mutational Spectrum Beyond Proline Substitutions. Pediatr Dermatol. 2025 Oct 14. doi: 10.1111/pde.70048. Epub ahead of print. PMID: 41088746.

Knowles A, Glass DA 2nd. Keloids and Hypertrophic Scars. Dermatol Clin. 2023 Jul;41(3):509-517. doi: 10.1016/j.det.2023.02.010. Epub 2023 Apr 4. PMID: 37236718.

Limmer EE, Knowles A, Deng J, Parthasarathy V, Kwatra SG, Glass DA 2nd. Atopic dermatitis is associated with an increased risk of keloids: A case-control study. J Am Acad Dermatol. 2023 May;88(5):1177-1179. doi: 10.1016/j.jaad.2022.12.013. Epub 2022 Dec 15. PMID: 36529374; PMCID: PMC10121727.

Limmer EE, Kerby E, Lies S, Limmer B, Limmer R, Teske N, Savory S, Reisch JS, Glass DA 2nd. The Keloid Area and Severity Index (KASI): an objective tool for the evaluation of keloids. Br J Dermatol. 2022 Nov;187(5):799-800. doi: 10.1111/bjd.21705. Epub 2022 Jul 6. PMID: 35700059.

Xing C, Kanchwala M, Rios JJ, Hyatt T, Wang RC, Tran A, Dougherty I, Tovar-Garza A, Purnadi C, Kumar MG, Berk D, Shinawi M, Irvine AD, Toledo-Bahena M, Agim NG, Glass DA 2nd. Biallelic variants in RNU12 cause CDAGS syndrome. Hum Mutat. 2021 Aug;42(8):1042-1052. doi: 10.1002/humu.24239. Epub 2021 Jun 15. PMID: 34085356.

Jagdeo J, Kerby E, Glass DA 2nd. Keloids. JAMA Dermatol. 2021 Jun 1;157(6):744. doi: 10.1001/jamadermatol.2020.4705. PMID: 33881453.

Tan A, Martinez Luna O, Glass DA 2nd. Pentoxifylline for the Prevention of Postsurgical Keloid Recurrence. Dermatol Surg. 2020 Oct;46(10):1353-1356. doi: 10.1097/DSS.0000000000002090. PMID: 31397783; PMCID: PMC7164298.

Glass DA 2nd. Current Understanding of the Genetic Causes of Keloid Formation. J Investig Dermatol Symp Proc. 2017 Oct;18(2):S50-S53. doi: 10.1016/j.jisp.2016.10.024. PMID: 28941494.

Li X, Orseth ML, Smith JM, Brehm MA, Agim NG, Glass DA 2nd. A Novel Homozygous Missense Mutation in HOXC13 Leads to Autosomal Recessive Pure Hair and Nail Ectodermal Dysplasia. Pediatr Dermatol. 2017 Mar;34(2):172-175. doi: 10.1111/pde.13074. PMID: 28297138.

Sun G, Berthelot C, Li Y, Glass DA 2nd, George D, Pandya A, Kurzrock R, Duvic M. Poor prognosis in non-Caucasian patients with early-onset mycosis fungoides. J Am Acad Dermatol. 2009 Feb;60(2):231-5. doi: 10.1016/j.jaad.2008.09.063. Epub 2008 Nov 20. PMID: 19026464.

Glass DA 2nd, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005 May;8(5):751-64. doi: 10.1016/j.devcel.2005.02.017. PMID: 15866165.

For a complete list of publications, please see my PubMed profile.

Scholarly Contributions

In addition to peer-reviewed publications, my work has included the development and stewardship of patient registries and biospecimen resources designed to support long-term investigation of complex skin disease. These efforts have emphasized rigorous phenotyping and responsible translational use.